God’s will is that we abstain from sexual immorality. There are numerous sins in this category, though I think Paul especially had in mind sex before marriage based on the transgressing and defrauding a brother comment in verse 6. But one thing all the sexual and gender corruption and confusion have in common is a wrong view of God.
Each one should have possession of his body and a priority on holiness and honor “not in the passion of lust like the Gentiles who do not know God” (1 Thessalonians 4:5).
Here the Gentiles/unbelievers have replaced theology proper with an alternative philosophy. Knowing God keeps things in order. He shows us what and who and when and how much to love. Those who know God do not despise the body God gave us, but those who do not know God often serve their body as god. Christians do not devalue sexual desire (at least not when we’re consistent with God’s Word, for example, Proverbs 5:18-19), but if we do not know God then sexual desire leads us like an ox to the slaughter (Proverbs 7:22-23).
The Bible, and even the law itself, are more than rules, the Dos and Do Nots. Revelation enables us to know God and to enjoy Him and it turns the lights on so that we can see what is truly pleasurable and truly fruitful. Knowing God is knowing what is better. Man’s chief end is also man’s chief blessing. Christian, God has called you to know Him and the blessings of holiness.